5 August 2020, Published on International Journal of Biological Macromolecules (IF 8.025) © Elsevier B.V.
Type II diabetes is a chronic metabolic disease. According to the International Diabetes Alliance, 451 million people (aged 18-99 years) suffered diabetes in worldwide in 2017, and it is expected to increase to 693 million by 2045 [1].
At present, most of the hypoglycemic drugs (synthetic insulin and Western medicine) used to treat diabetes might cause side-effects such as hypoglycemia and myocardial infarction. As materials of tonics or dietary supplements, Chinese herbal medicines that used both as food and medicine have fewer toxic effects and could assist in treatment of diabetes [2,3]. Dendrobium officinale is used both as food and medicine for many years and widely distributed in tropical and subtropical regions of Europe/Asia/Oceania [4]. It is rich in active ingredients such as polysaccharides, polyphenols, alkaloids, and glycosides. In Dendrobium officinale, polysaccharides are the main active ingredient, accounting for 20% to 40% of the total compounds [5]. Polysaccharides of Dendrobium officinale have antioxidant, immunomodulatory, liver protection, improvement of chronic kidney disease and regulation of the intestinal microbiota.
Professor Nie Shaoping’s team from Nanchang University published “Dendrobium officinale polysaccharide ameliorates the liver metabolism disorders of type II diabetic rats” in the International Journal of Biological Macromolecules. It provided a reference for the follow-up researches and applications of Dendrobium officinale polysaccharide (DOP) in the prevention and treatment of type II diabetes. In this study, the researchers combined metabolomics and lipidomics methods to study the effect of DOP on metabolic homeostasis of the liver of rats with type II diabetes. They also studied the effects of DOP in oxidative stress, inflammatory response and metabolic regulation in treatment of type II diabetes. The researchers designed an experimental model of type II diabetes rats through combination of high-fat diet and STZ. On one hand, Lipidomic analysis showed that oral DOP reduced metabolic disturbance of fatty acids, glyceryl oils (diacylglycerol and triacylglycerol) and glycerol phospholipids (phosphatidylcholine and phosphatidylethanolamine) in rats with type II diabetes. On the other hand, Metabolomics analysis showed that oral DOP could regulate and balance the metabolism of ceramides and bile acids (deoxycholic acid, taurine, and bile acid) in rats with type II diabetes. In addition, it was improved for symptoms of oxidative stress, inflammatory, and liver fat accumulation by intake DOP in rats with type II diabetes. For the dose of DOP, the improvement was optimal when 80 mg/kg BW of DOP was for oral use, which was similar with the effect of diformin. These results suggested that the study of DOP application had important implications for the intervention of type II diabetes.
Article
Yang, J., Chen, H., Nie, Q., Huang, X., & Nie, S.. Dendrobium officinale polysaccharide ameliorates the liver metabolism disorders of type II diabetic rats. International journal of biological macromolecules. 2020, 164, 1939-1948.
Reference
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